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Glia

An astrocytic generation gap

Nature Reviews Neuroscience volume 14, page 157 (2013)Cite this article

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Studies that showed evidence of mGluR5-dependent increases in intracellular Ca2+ in astrocytes in response to neural activity have mainly been performed in slices taken from young animals or from astrocyte cultures obtained from fetal brain tissue. Among other issues, these approaches raised the question of whether the effect could be limited to the developing brain, and the authors set out to address this question.

these data point to distinct forms of neuron–astrocyte signalling in developing and adult brains

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References

ORIGINAL RESEARCH PAPER

  1. Sun, W. et al. Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science 339, 197–200 (2013)

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FURTHER READING

  1. Hamilton, N. B. & Attwell, D. Do astrocytes really excocytose neurotramsmitters? Nature Rev. Neurosci. 11, 227–238 (2010)

    Article  CAS  Google Scholar 

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Authors
  1. Leonie Welberg
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Welberg, L. An astrocytic generation gap. Nat Rev Neurosci 14, 157 (2013). https://doi.org/10.1038/nrn3446

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