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Neuronal circuits

Deciphering striatal innervation

Nature Reviews Neuroscience volume 14, page 523 (2013)Cite this article

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The direct and indirect striatal pathways act in opposition to each other to regulate motor learning. They comprise different classes of medium spiny neuron (MSN), but it is unclear whether these classes are differentially innervated by other brain areas. Using a monosynaptic rabies virus system, Wall et al. found that some brain areas, such as the motor cortices, preferentially innervated the indirect pathway, whereas others, such as the limbic regions, preferentially innervated the direct pathway. Together, these 'maps' indicate that information segregation can occur above the level of MSNs.

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References

  1. Wall, N. R. et al. Differential innervation of direct- and indirect-pathway striatal projection neurons. Neuron http://dx.doi.org/10.1016/j.neuron.2013.05.014 (2013)

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Authors
  1. Darran Yates
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Yates, D. Deciphering striatal innervation. Nat Rev Neurosci 14, 523 (2013). https://doi.org/10.1038/nrn3562

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