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Vasculitis

Renal involvement in granulomatosis with polyangiitis—role of ANCA isotype and Fc receptor genotype

Nature Reviews Nephrology volume 8, page 63 (2012)Cite this article

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Granulomatosis with polyangiitis (GPA) is associated with a broad range of clinical manifestations, including renal disease. New findings by James Kelley et al. at the University of Alabama at Birmingham, working with the NIH-supported Vasculitis Clinical Research Consortium (VCRC) led by Peter Merkel from Boston University, suggest that antineutrophil cytoplasmic antibody (ANCA) isotype and Fc receptor (FcR) genotype influences disease severity and renal involvement. “These findings provide a whole new way, and mechanism for how ANCAs can contribute to the pathogenesis of GPA”, explains Jeffrey Edberg of the study group.

...it was a logical next step to probe the IgA–FCAR axis in patients with GPA

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ORIGINAL RESEARCH PAPER

  1. Kelley, J. M. et al. IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.1109227109

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  1. Susan J. Allison
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Allison, S. Renal involvement in granulomatosis with polyangiitis—role of ANCA isotype and Fc receptor genotype. Nat Rev Nephrol 8, 63 (2012). https://doi.org/10.1038/nrneph.2011.209

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  • DOI: https://doi.org/10.1038/nrneph.2011.209

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