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Immunology

ACE in neutrophil antibacterial defence

Nature Reviews Nephrology volume 13, page 382 (2017)Cite this article

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ACE can do many things that affect the immune response

Angiotensin-converting enzyme (ACE) inhibitors are widely used to lower blood pressure and slow the progression of renal disease. New research, however, has revealed an important role for ACE in the antibacterial effectiveness of neutrophils. “ACE can do many things that affect the immune response,” says Kenneth Bernstein. “We have previously shown that mice that overexpress ACE in monocytes and macrophages have an increased antitumour response and enhanced resistance to infection.”

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References

  1. Khan, Z. et al. Angiotensin converting enzyme enhances the oxidative response and bactericidal activity of neutrophils. Blood http://doi.org/10.1182/blood-2016-11-752006 (2017)

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  1. Susan J. Allison
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Allison, S. ACE in neutrophil antibacterial defence. Nat Rev Nephrol 13, 382 (2017). https://doi.org/10.1038/nrneph.2017.80

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