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Regulating osteoclast differentiation to prevent bone loss

Nature Reviews Rheumatology volume 10, page 66 (2014)Cite this article

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Ibrutinib—an orally available anti-cancer drug that inhibits Btk—blocks osteoclast differentiation and function, and suppresses osteoclastic bone resorption, according the results of a new study. “Although it was shown in previous studies that Btk inhibitors may be effective in the treatment of osteoporosis, this study showed that the orally available inhibitor can exert this bone sparing effect well, providing a good possibility of treating osteoporosis with this drug,” explains Hiroshi Takayanagi, lead author of the study.

...ibrutinib regulates the expression of osteoclast-associated genes and suppresses bone destruction...

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References

  1. Shinohara, M. et al. The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss. Bone 10.1016/j.bone.2013.11.025

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  1. Bryony Jones
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Jones, B. Regulating osteoclast differentiation to prevent bone loss. Nat Rev Rheumatol 10, 66 (2014). https://doi.org/10.1038/nrrheum.2013.206

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