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Developmental biology

Is there such a thing as a cartilage-specific knockout mouse?

Nature Reviews Rheumatology volume 10, pages 702–704 (2014)Cite this article

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The strongest evidence yet that hypertrophic chondrocytes can turn into osteoblasts could affect not only our understanding of skeletal development, but also the use of research tools thought to be cartilage-specific.

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Figure 1: Osteochondral cell fate.

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Acknowledgements

The authors' work is funded by the Canadian Institutes of Health Research (M.A.P., F.B.) and Canada Research Chairs (F.B.).

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  1. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, N6A 5C1, ON, Canada

    Michael A. Pest & Frank Beier

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  1. Michael A. Pest
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  2. Frank Beier
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Correspondence to Frank Beier.

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The authors declare no competing financial interests.

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Pest, M., Beier, F. Is there such a thing as a cartilage-specific knockout mouse?. Nat Rev Rheumatol 10, 702–704 (2014). https://doi.org/10.1038/nrrheum.2014.168

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