Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Intrinsic metal binding by a spliceosomal RNA

Nature Structural Biology volume 9, pages 498–499 (2002)Cite this article

An Erratum to this article was published on 01 September 2002

A conserved stem-loop in the spliceosomal U6 snRNA is thought to play an important role in splicing of mRNA precursors. Recent work describes structural features of this stem-loop and highlights the significance of a previously noted catalytically important metal ion.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: a, The base paired structure of the U6 intramolecular stem-loop in yeast (right) and domain V of the group II intron aI5γ (left).

References

  1. Nilsen, T.W. RNA Structure and Function (eds Simons, R. & Grunberg-Manago, M.) 279–307 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor; 1998).

    Google Scholar 

  2. Burge, C.B., Tuschl, T.H. & Sharp, P.A. RNA World II (eds Gesteland, R.F., Cech, T.R. & Atkins, J.F.) 525–560 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor; 1998).

    Google Scholar 

  3. Villa, T., Pleiss, J.A. & Guthrie, C. Cell 109, 149–152 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Huppler, A., Nikstad, L.J., Allman, A.M., Brow, D.A. & Butcher, S.E. Nature Struct. Biol. 9, 431–435 (2002).

    Article  CAS  PubMed  Google Scholar 

  5. Valadkhan, S. & Manley, J.L. Nature 413, 701–707 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Jacquier A. Biochimie 78, 474–487 (1996).

    Article  CAS  PubMed  Google Scholar 

  7. Uhlenbeck, O.C. Nature 346, 613–614 (1990).

    Article  CAS  PubMed  Google Scholar 

  8. Jucker, F.M. & Pardi, A. RNA 1, 219–222 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Fabrizio, P. & Abelson, J. Nucleic Acids Res. 20, 3659–3664 (1992).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chanfreau, G. & Jacquier, A. Science 266, 1383–1387 (1994).

    Article  CAS  PubMed  Google Scholar 

  11. Yu, Y.T., Maroney, P.A., Darzynkiwicz, E. & Nilsen, T.W. RNA 1, 46–54 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Gordon, P.M. & Piccirilli, J.A. Nature Struct. Biol. 8, 893–898 (2001).

    Article  CAS  PubMed  Google Scholar 

  13. Yean, S.L., Wuenschell, G., Termini, J. & Lin, R.J. Nature 408, 881–884 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Sigel, R.K., Vaidya, A. & Pyle, A.M. Nature Struct. Biol. 7, 1111–1116 (2000).

    Article  CAS  PubMed  Google Scholar 

  15. Zhang, L. & Doudna, J.A. Science 295, 2084–2088 (2002).

    Article  CAS  PubMed  Google Scholar 

  16. Wolff, T. & Bindereif, A. Genes Dev. 7, 1377–1389 (1993).

    Article  CAS  PubMed  Google Scholar 

  17. Fortner, D.M., Troy, R.G. & Brow, D.A. Genes Dev. 8, 221–233 (1994).

    Article  CAS  PubMed  Google Scholar 

  18. McPheeters, D.S. RNA 2, 1110–1123 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Sun, J.S. & Manley, J.L. RNA 3, 514–526 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Shukla, G.C. & Padgett, R.A. RNA 5, 525–538 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Jaeger, L., Michel, F. & Westhof, E. J. Mol. Biol. 236, 1271–1276 (1994).

    Article  CAS  PubMed  Google Scholar 

  22. Murphy, F.L. & Cech, T.R. J. Mol. Biol. 236, 49–63 (1994).

    Article  CAS  PubMed  Google Scholar 

  23. Costa, M. & Michel, F. EMBO J. 14, 1276–1285 (1995).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Doherty, E.A., Batey, R.T., Masquida, B. & Doudna, J.A. Nature Struct. Biol. 8, 339–343 (2001).

    Article  CAS  PubMed  Google Scholar 

  25. Boudvillain, M., de Lencastre, A. & Pyle, A.M. Nature 406, 315–318 (2000).

    Article  CAS  PubMed  Google Scholar 

  26. Madhani, H.D. & Guthrie, C. Genes Dev. 8, 1071–1086 (1994).

    Article  CAS  PubMed  Google Scholar 

  27. Valadkhan, S. & Manley, J.L. RNA 6, 206–219 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Biological Sciences, Columbia University, New York, 10027, New York, USA

    Saba Valadkhan & James L. Manley

Authors
  1. Saba Valadkhan
    View author publications

    Search author on:PubMed Google Scholar

  2. James L. Manley
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Valadkhan, S., Manley, J. Intrinsic metal binding by a spliceosomal RNA. Nat Struct Mol Biol 9, 498–499 (2002). https://doi.org/10.1038/nsb0702-498

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nsb0702-498

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing