In response to DNA double-strand breaks, histone H1.2 translocates from the nucleus into the cytoplasm, leading to the mitochondrial release of cytochrome c and subsequent apoptosis of the cell. The molecular underpinnings for these processes remain enigmatic.
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Yan, N., Shi, Y. Histone H1.2 as a trigger for apoptosis. Nat Struct Mol Biol 10, 983–985 (2003). https://doi.org/10.1038/nsb1203-983
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DOI: https://doi.org/10.1038/nsb1203-983
