New work shows that a toxin that normally kills the yeast Saccharomyces cerevisiae by cleavage of tRNA substrates can be neutralized by RNA ligases that repair the damage, suggesting that these ligases may have a more general role in tRNA repair in the cell.
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Acknowledgements
The author is grateful to M. Baker, I. Chernyakov and E. Grayhack for comments on this manuscript. Work in this laboratory is supported by US National Institutes of Health grant GM52347.
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Phizicky, E. Waste not, want not: a case for tRNA repair. Nat Struct Mol Biol 15, 783–784 (2008). https://doi.org/10.1038/nsmb0808-783
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DOI: https://doi.org/10.1038/nsmb0808-783
