Figure 1 | Oncogene

Figure 1

From: Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2

Figure 1

Proliferation of epidermal cells of WT and Jdp2KO mice in the TPA-induced epidermal thickness in vivo. (A) WT and Jdp2KO mice were shaved, painted four times with TPA or acetone and subjected to punch biopsy for pathology examination. Skins from WT mice and Jdp2KO mice were painted with acetone or 8.1 nmol TPA. Ten areas of skin in mid-power field were randomly selected in each section and assayed for their epidermal thickness (n=3 each group, H&E; scale bar=100 μm). (B) Immunostaining of the epidermis with antibodies against PCNA. (C) The thickness and PCNA-positive cell number of the epidermis was measured. Data were sketched in a chart showing the mean±s.e. *P<0.05, **P<0.001. KO, Jdp2-knockout; PCNA, proliferation cell nuclear antigen; TPA, 12-O-tetradecanoylphorbol 13-acetate; WT, wild type.

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