Figure 8
From: The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer
KDM4B regulates peritoneal seeding of ovarian cancer. Hypothesized mechanism of KDM4B signaling to promote ovarian cancer progression. Briefly, hypoxia induces the expression of KDM4B, catalyzing demethylation of histone H3K9me3 at target promoters and regulating expression of genes that facilitate the seeding of metastases in the viscera and peritoneal wall.
