Table 2 Summary of statistics for phospho-PEA-15 and β-catenin expressiona

From: PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin

Analysis categories

Tumor n (%)

Normal n (%)

P

 

High

Low

 

Normal vs tumor

Total PEA-15-pS104

48/60 (80.0)

12/60 (20.0)

0/10 (0.0)

 

Tumor grade

 I

10/13

3/13

 

0.0004

 II

20/26

6/26

 

<0.0001

 III

18/21

3/21

 

<0.0001

Total PEA-15-pS116

36/60 (60.0)

24/60 (40.0)

9/10 (90.0)

0.08

β-catenin

21/60 (35.0)

39/60 (65.0)

5/10 (50.0)

0.48

Double phopshorylation status

PEA-15 high-pS104/low-pS116

17/60 (25.8)

 

0/10 (0.0)

0.1043

PEA-15 low-pS104/high-pS116

2/60 (3.3)

 

9/10 (90.0)

 

Tumor grade

 I

0/13

  

<0.001

 II

2/26

  

<0.001

 III

0/21

  

<0.001

PEA-15 high-pS104/high-pS116

33/60 (55)

 

0 (0.0)

 

Tumor grade

 I

5/13

  

0.046

 II

15/26

  

0.002

 III

13/21

  

0.001

PEA-15 low-pS104/low-pS116

8/60 (13.3)

 

1/10 (10.0)

1

  1. Note: Bonferroni method was used to adjust for multiple comparisons, therefore only P-values <0.05/9=0.0056 was considered statistically significant in the above table. The P-values highlighted in bold are considered significant.
  2. Samples are categorized according to their expression of markers (low intensity=0 or 1 and high intensity=2 or 3).
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