Oncogenesis

Table 1 mtDNA point mutations, mtDNA large deletions and BRCA2 protein levels in prostate carcinoma specimens

From: Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2

Point mutations
Sample	Base change	Amino-acid change	Gene	Het	PSIC	Somatic	Variability	ID	Large deletions (n)	mtDNA content (%)	BRCA2 protein (%)
BPH 1	A15929G	—	MT-TT	−		n.a.	0.002	PA_XX_XX_183	0	83	45
BPH 2	T12713C	I126T	MT-ND5	−	0.003	n.a.	0.000	PA_XX_XX_188	2	98	61
BPH 3	G9300A	A32T	MT-COIII	−	0.000	n.a.	0.019	PA_XX_XX_184	0	100	62
BPH 4	T14501C	I58T	MT-ND6	−	0.514	n.a.	0.000	PA_XX_XX_185	0	98	89
BPH 5	A12634G	I100V	MT-ND5	−	0.925	n.a.	0.010	PA_XX_XX_186	1	100	84
	A13630G	T432A	MT-ND5	−	0.527	n.a.	0.006
	T8668C	W48R	MT-ATP6	−	0.999	n.a.	0.004
BPH 6	T5160C	S231P	MT-ND2	−	0.986	n.a.	0.000	PA_XX_XX_187	2	91	100
PCa 1	None							PA_XX_XX_168	7	34	5
PCa 2	T11204C	F149L	MTND4	−	0.000	Y	0.020	PA_XX_XX_169	6	98	5
PCa 3	None							PA_XX_XX_170	5	56	13
PCa 4	None							PA_XX_XX_171	5	89	11
PCa 5	C9739T	A178V	MTCOIII	−	0.018	N	0.000	PA_XX_XX_172	5	76	16
PCa 6	T11253C	I165T	MTND4	−	0.001	N	0.021	PA_XX_XX_173	6	98	16
PCa 7	G15428A	D228N	MTCYTB	+	0.999	Y	0.000	PA_XX_XX_174	13	100	8
	T12631G	S99A	MTND5	−	0.003	N	0.001
PCa 8	None							PA_XX_XX_175	9	39	0.5
PCa 9	None							PA_XX_XX_176	10	79	0.5
PCa 10	None							PA_XX_XX_177	11	82	0.5
PCa 11	None							PA_XX_XX_178	13	60	0.5
PCa 12	G9738A	A178T	MTCOIII	−	0.219	N	0.007	PA_XX_XX_179	14	65	0.5
PCa 13	None							PA_XX_XX_180	7	81	7
PCa 14	A14220C	L152P	MTND6	−	0.999	N	0.000	PA_XX_XX_181	9	80	10
	G5849A	—	MT-TY	+		N	0.000
PCa 15	None							PA_XX_XX_182	16	31	0.25

Abbreviations: BPH, benign prostate hyperplasia; Het, heteroplasmy; n.a., information not available; PCa, prostate carcinoma.

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