Figure 2 | Oncogenesis

Figure 2

From: miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway

Figure 2

Upregulated AREG and downregulated miR-34c-5p expression levels were observed in SKOV-I6 and OVS1 sphere cells. (a) Genome-wide gene expression in OVS1 cell line was analyzed by microarray analysis. The expression of AREG is 6.94-fold upregulated in OVS1 sphere cells compared with their parental cells. The ranges of fold are listed below the figure. (b) Genom-wide microRNAs expression in OVS1 cell line was analyzed by microarray analysis. The expression of miR-34c-5p in OVS1 sphere cells showed -2.26-fold change compared with their parental cells. The ranges of fold are listed below the figure. (c) The mRNA expression levels of AREG and miR-34c-5p in parental SKOV-I6 and OVS1 cells and their sphere cells were analyzed by qRT–PCR. Actin and RNU6B were used as internal controls respectively. Histograms represent means±s.d. from three independent experiments (*P<0.05; **P<0.01).

Back to article page