Figure 1
From: Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ
Identification of nucleolar localization signal (NoLS) in Fbw7. Fbw7 isoforms vary in their N-terminal sequence. The sequences of Fbw7α (a), Fbw7β (b) and Fbw7γ (c) were subjected to the NoD algorithm in order to identify putative NoLS (Scott et al.,20). The server identifies a full NoLS in Fbw7γ only (score above 0.8) while only a partial one in Fbw7α. Fbw7γ is known to be nucleolar while Fbw7α is located in the nucleoplasm. In d the underlined sequences correspond to the putative NoLS. PSIPRED secondary structure predictions for the three isoforms, in the regions of interest, are shown in e.
