Table 2 Dissociation constants for the complexes between the Fbw7γ* peptide and Nter-NPM1 mutants
From: Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ
Protein | KD (μ m) |
|---|---|
Nter-NPM1 | 3.2±0.6 |
D36A | 10.8±2.6 |
E37A | 12.5±1.4 |
E39A | 6.2±1.5 |
E93A | 5.0±1.6 |
E121A | 13.3±3.8 |
D36A-E39A | 13.5±2.0 |
D36A-E93A | 8.4±1.5 |
E39A-E93A | 7.6±1.9 |
D36A-E39A-E93A | 22.0±3.0 |
D36A-E37A-E39A-E93A | 151.5±20.5 |
D36A-E39A-E93A-E121A | 224.3±35.9 |
D36A-E37A-E39A-E93A-E121A | 653.7±46.9 |
