Table 3 Dissociation constants for the complexes between Nter-NPM1 selected mutants and the CENP-W* and Tat* peptides

From: Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ

 

CENP-W* KD (μ m)

Tat* KD (μ m)

Nter-NPM1

6.2±0.9

2.4±0.5

D36A-E39A-E93A

18.4±2.6

11.1±2.1

D36A-E37A-E39A-E93A

71.4±9.1

57.4±7.0

D36A-E39A-E93A-E121A

82.8±5.6

63.8±5.0

D36A-E37A-E39A-E93A-E121A

734.0±158.0

642.6±70.8

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