Abstract
To investigate the short-range interactions in elastin, conformational energy calculations using ECEPP were carried out for elastin model tetrapeptide, Ac-Val-Pro-Gly-Gly-NHMe. The DCC* conformation is the most favorable one for Val-Pro-Gly portion in the model tetrapeptide. The bend in trans Ac-Val-Pro-Gly-Gly-NHMe are recognized at Pro-Gly and Gly-Gly portions with higher probability. Favorable bend type at Pro-Gly is type II and type V which is a distorted type II β-bend, and the summation of these bend probabilities is 0.60 which corresponds to the tendency of forming a type II β-bend at Pro-Gly supposed by experimental works in solution and crystal structure.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
T. Weis-Fogh and S. O. Anderson, Nature, 227, 718 (1970).
W. R. Gray, L. B. Sandberg, and J. A. Foster, Nature, 246, 461 (1973).
J. A. Foster, E. Bruenger, W. R. Gray, and L. B. Sandberg, J. Biol. Chem., 248, 287 (1973).
D. W. Urry and M. M. Long, CRC Crit. Rev. Biochem., 4, 1 (1976).
D. W. Urry, J. Protein Chem., 3, 403 (1984).
M. A. Khaled, V. Renugopalakrishnan, and D. W. Urry, J. Am. Chem. Soc., 98, 7547 (1976).
M. A. Khaled and D. W. Urry, Biochem. Biophys. Res. Commun., 70, 485 (1970).
F. A. Momany, R. F. McGuire, A. W. Burgess, and H. A. Scheraga, J. Phys. Chem., 79, 2361 (1975).
IUPAC-IUB Commission on Biochemical Nomenclature, Biochemistry, 9, 3471 (1970).
M. J. D. Powell, Computer J., 7, 155 (1964).
S. S. Zimmerman, M. S. Pottle, G. Nemethy, and H. A. Scheraga, Macromolecules, 10, 1 (1977).
S. S. Zimmerman and H. A. Scheraga, Biopolymers, 16, 811 (1977).
V. F. Bystrov, Prog. NMR Spectroscopy, 10, 41 (1976).
M. Oka, G. T. Montelione, and H. A. Scheraga, J. Am. Chem. Soc., 106, 7959 (1984).
S. S. Zimmerman and H. A. Scheraga, Biopolymers, 17, 1871 (1978).
H. Ayato, I. Tanaka, and T. Ashida, J. Am. Chem. Soc., 103, 5902 (1981).
Y. Yagi, I. Tanaka, T. Yamane, and T. Ashida, J. Am. Chem. Soc., 105, 1242 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Oka, M., Baba, Y., Kagemoto, A. et al. Theoretical Conformational Analysis on Elastin Model Tetrapeptide Ac-Val-Pro-Gly-Gly-NHMe. Polym J 21, 585–591 (1989). https://doi.org/10.1295/polymj.21.585
Issue date:
DOI: https://doi.org/10.1295/polymj.21.585
Keywords
This article is cited by
-
Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-D-Ala-Cys-NHMe with Disulfide Linkage
Polymer Bulletin (1997)
-
Theoretical conformational analysis on elastin analogue tetrapeptide Ac-Ala-Pro-Gly-Gly-NHMe
Polymer Bulletin (1991)
-
Theoretical conformational analysis of poly(val-pro-gly-gly) with cis peptide bond at val-pro portion
Polymer Bulletin (1991)
