Abstract
The prevention of the triggering effect of Bordetella pertussis vaccine on the induction of homocytotropic antibody to ragweed and horse serum was studied in inbred DA and random bred Sprague Dawley rats.
Rats received one of the following treatments:I- pertussis vaccine intraperitoneally(IP) (0.01 ml/g body weight. Vaccine contained 10×109 phase I organisms/ml ); II- pertussis IP and antigen (1:10 giant ragweed extract, 0.005 ml/g BW or horse serum 1 ml/rat) in the footpads; or III- antigen (giant ragweed extract or horse serum ) in the footpads. Rats were bled 10 days later and serum collected. The presence of homocytotropic antibody against ragweed or horse serum was tested by 48 hour passive cutaneous anaphylaxis on normal adult recipients. Only rats which received antigen simultaneously with pertussis vaccine (II) formed homocytotropic antibody which was specific for the antigen used. If, however, the rats(II) were fed antigen, for 5-7 days, 2 weeks prior to sensitization, they failed to produce homocytotropic antibody to the antigen which they were fed with.
These results suggest that the induction of homocytotropic antibody formation to an antigen can be prevented by pre-feeding the antigen.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
David-Faridy, M., Haworth, J. PREVENTION OF HOMOCYTOTROPIC ANTIBODY RESPONSE IN RATS. Pediatr Res 8, 411 (1974). https://doi.org/10.1203/00006450-197404000-00428
Issue date:
DOI: https://doi.org/10.1203/00006450-197404000-00428
