Abstract
During an outbreak of serogroup C sulfonamide-resistant Neisseria meningitidis in the city of Sao Paulo, Brazil, serogroup C meningococcal polysaccharide was given to 67,000 children between 6 and 35 months of age, using jet injector guns and a 50 microgram dose without any preservative. An equivalent number of children received a diphtheria-tetanus toxoid injection. Allocations of children to the vaccine or control groups were made by the use of random number tables at 24 vaccine centers throughout the city during the period December 12-22, 1972.
Serologic studies of 133 children receiving the vaccine or the control materials were completed using a radioimmunoassay technique and indicated that the program of vaccination was effective in initiating serologic response.
After 11 months of follow-up, 32 cases of culture- or counterimmunoelectrophoresis-proven serogroup C meningococcal disease have occurred in children who took part in the vaccine trial. Although there is no indication that the vaccine was effective in preventing disease in the children from 6 to 23 months of age, those between 24 and 35 months of age appeared to be protected. The trial is continuing.
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Taunay, A., Galvao, P., de Morais, J. et al. DISEASE PREVENTION BY MENINGOCOCCAL SEROGROUP C POLYSACCHARIDE VACCINE IN PRESCHOOL CHILDREN: RESULTS AFTER ELEVEN MONTHS IN SAO PAULO, BRAZIL. Pediatr Res 8, 429 (1974). https://doi.org/10.1203/00006450-197404000-00537
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DOI: https://doi.org/10.1203/00006450-197404000-00537
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