Abstract
Extract: Changes of incorporation of [3H]thymidine into brain DNA were studied in C57BL/6J mice after perinatal neocerebellar lesion. The destruction of part of the left neocerebellar cortex caused temporary increase of the specific radioactivity of DNA extracted from neocerebellum (15.22 ± 0.57 cpm/mg DNA vs. 4.83 ± 0.40 cpm/mg DNA in controls), from left hemisphere (9.86 ± 0.45 cpm/mg DNA in operated vs. 4.22 ± 0.40 cpm/mg DNA in controls), and from right hemisphere (11.75 ± 0.52 cpm/mg DNA in operated vs. 4.78 ± 0.39 cpm/mg DNA in controls). The labeled DNA was localized both in glia and in neurons in different brain areas. In animals operated upon in adult age, no changes in labeling of brain DNA were observed.
Speculation: It is possible that the described changes of the metabolism of the brain DNA are necessary and precede the “spontaneous nervous reorganization” necessary for the restitution of functions of the damaged brain.
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Reiniš, S. Incorporation of [3H]Thymidine into Brain DNA after Cerebellar Damage. Pediatr Res 9, 807–811 (1975). https://doi.org/10.1203/00006450-197511000-00001
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DOI: https://doi.org/10.1203/00006450-197511000-00001
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