Abstract
Increase activity of the renin/ aldosterone system in the neonatal period is now well established in both animals and man, but the control mechanisms involved are poorly understood. We have therefore monitored plasma renin activity /PRA/ and aldosterone concentration /PAldo/ in 8 newborns undergoing 12 exchange transfusions. PRA and PAldo were measured before and at 5, 10, 15 and 30 min after the withdrawal or injection of 7ml blood/kg birthweight immediately before exchange transfusion. Mean PRA increased to 140% and decreased to 60% of the resting values following withdrawal or injection of blood respectively. Mean PAldo values did not change significantly during the same period. Thus the renin-angiotensin system in the newborn infant is responsive to changes in blood volume. The absence of PAldo changes may be due to the shortness of the observation period.
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J, M., Milner, R., Rajani, K. et al. EFFECTS OF ACUTE BLOOD VOLUME CHANGE ON PLASMA RENIN AND ALDOSTERONE IN THE NEWBORN. Pediatr Res 9, 861 (1975). https://doi.org/10.1203/00006450-197511000-00054
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DOI: https://doi.org/10.1203/00006450-197511000-00054
