Abstract
During treatment with monocomponent Lente and Semilente insulins for on the average 2 years, seven out of 14 diabetic children developed antibodies to insulin /IgG binding exceeding 0.05 mU/ml of serum/, and four had a borderline response. The positive cases usually had a low antibody formation. A 10 year old girl, however showed a strong antibody response, the IgG binding being 4.92 mU/ml at one and 11.16 mU/ml at two years after the start of MC-insulin therapy. She had no severe infection in the history. In order to evaluate the capacity to form antibodies against some other antigens than insulin, a booster dose of 0.1 ml tetanus vaccine was given to her and to six other cases. Three weeks later the tetanus antibody level had risen 30-fold in the first case, whereas in the others the rise was 2.5–5 fold. Thus the first mentioned individual formed antibodies extraordinarily both to insulins of high purity and to tetanus toxoid. Diabetic children differ from adults in their tendency to antibody formation during MC-insulin therapy.
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Akerblom, H., Koivisto, V. & Kouvalainen, K. FORMATION OF INSULIN ANTIBODIES DURING TREATMENT WITH MONOCOMPONENT INSULINS IN CHILDREN. Pediatr Res 9, 870 (1975). https://doi.org/10.1203/00006450-197511000-00111
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DOI: https://doi.org/10.1203/00006450-197511000-00111
