Abstract
53 patients with SLE have been followed for 7 months to 10 years and have undergone at least one renal biopsy (RB). Hlsto-pathologic classification of initial RB was: I normal, 9 Type I (proliferation without deposits), 5 Type II (membranous), and 38 Type III (proliferation with deposits). Each patient received prednisone. 13 received azathioprine or cyclophosphamide. Subsequent RB or post-mortem examination in 15 showed progression in 4 (I with Type I, 2 with Type II and 1 with Type III), improvement in 4 with Type III and no significant change in 7. 4 developed renal failure, 3 of whom expired, 8 died of non-renal causes and 1 is azotemic. The remainder are alive. Chronic renal failure and persistent active renal disease occurred only with Types II and III. The low incidence of renal failure (7.5%) in this large series of patients with SLE despite the preponderance of Type III suggests a better prognosis than previously reported.
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Aronson, A., Kallen, R., Grossman, B. et al. RENAL HISTOPATHOLGY AND CLINICAL COURSE OF 53 CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). Pediatr Res 11, 546 (1977). https://doi.org/10.1203/00006450-197704000-01060
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DOI: https://doi.org/10.1203/00006450-197704000-01060
