Abstract
Glomerular permeability to neutral polydisperse polyvinylpyrrolidone 125I (PVP) was studied in Foreman rats with and without autologous immune complex glomerulonephritis (AIC). The Foreman rat generally develops milder disease than other strains. However, all AIC rats studied were nephrotic with proteinuria in excess of SOmg/24 hrs. PVP clearance (MW 8000-85000) was determined by column chromatography and compared to simultaneous inulin clearance (Cin). Particle diameter (Å) was calculated by deriving RS, radius of equivalent sphere, for each PVP fraction. Clearances were performed without volume expansion, using iso-volemic replacement of blood samples.
Cin was the same in AIC and controls. Mean permeability to molecules > 4oÅ was only slightly increased in AIC (p > .5). In contrast, permeability to molecules < 4oÅ was decreased, as previously reported with PVP in idiopathic nephrotic syndrome (INS)1 and with dextran in nephrotoxic serum nephritis.2 cpvp < 25Å approached 100% Cin in controls, whereas this occurred in AIC only at < 15Å (p < .05); i.e. passage of low MW PVP particles in AIC was restricted but not as much as in INS, where CPVP never approached that of Cin. Permeability changes associated with the presence of immune complexes in AIC may obscure the restriction of small MW PVP found when there is foot-process disease alone.
1. Robson, A.M., et al: JCI 54:1190, 11/74.
2. Chang, R.L.S., et al: JCI 57:1272, 5/76.
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Ingelfinger, Julie, R., Eveline, E. et al. GLOMERULAR PERMEABILITY IN AUTOLOGOUS IMMUNE COMPLEX (AIC) NEPHRITIS. Pediatr Res 11, 552 (1977). https://doi.org/10.1203/00006450-197704000-01093
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DOI: https://doi.org/10.1203/00006450-197704000-01093
