Abstract
Renal function was studied in 30-50 day old rate exposed to Pb from birth. Dam's diet contained 4% lead carbonate until Day 16, and 0.4% thereafter. Post weaning pups were fed 0.4% lead carbonate. Lead fed pups had blood lead levels of 96 ± 24 μg Pb/100 ml whole blood compared to pair fed controls of 7 ± 1 μg Pb%*. As shown in the table certain indices of renal function were not affected by lead exposure.
However, when challenged with 24-hour water restriction, Pb-fed rats had urine volumes of 5.05 ± 0.36 ml/24 hrs and urine osmolalities of 1216 ± 160 mOsmols/1 compared to 1.90 ± .33* and 1967 ± 93*, respectively, for controls. In addition, following extracellular volume expansion with saline, fractional Na excretion was greater in Pb fed animals (.091 ± .01) than in controls (.039 ± .006*). Thus, Pb exposure to newborn rats results in altered tubular function that limits the ability of the animal to respond to changes in water and Na intake. (Supported by NIH grants ES00972 and ES00159.)
*p <.01
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Johnson, D., Kleinman, L. THE EFFECTS OF LEAD-EXPOSURE ON RENAL FUNCTION OF YOUNG RATS. Pediatr Res 11, 552 (1977). https://doi.org/10.1203/00006450-197704000-01095
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DOI: https://doi.org/10.1203/00006450-197704000-01095
