Abstract
Although previous studies have demonstrated that total lung water decreases with growth, the possibility that this may have resulted solely from changes in pulmonary blood water (PBW) has not been excluded. Since extravascular lung water (ELW) may be the more important determinant of lung function, we measured ELW at 2, 8, 14, 22, 28, 180 and 365 days in a total of 66 rats. Following intravenous injection of 51Cr tagged red blood cells, radioactivity as well as wet and dry weight of samples of blood and lung were measured to determine ELW and PBW.
Regression analysis revealed a significant and rapid fall in ELW from 2 to 28 days (slope = -0.028) and a slower but significant decline subsequently through 180 days (slope= -0.002) p<0.01. We conclude that there is a decline in both ELW and PBW with growth throughout the first 6 months of life in the rat.
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Winnik, G., Epstein, S., Epstein, R. et al. CHANGE IN EXTRAVASCULAR LUNG WATER WITH GROWTH IN RATS. Pediatr Res 11, 581 (1977). https://doi.org/10.1203/00006450-197704000-01269
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DOI: https://doi.org/10.1203/00006450-197704000-01269
