EFFECTS OF TREATMENT WITH EMULSIFIED FAT SUSPENSION (IL) ON PIASMA FIBRINOGEN (F)

Abstract

A rise in circulating triglyceride or free fatty acids (FFA) is often associated with increased F, and recent data indicate that FFA may be involved in regulation of F synthesis. F was measured in young rats allowed access to regular chow while treated with a 10% suspension of IL (3 to 6 g/kg/day) administered P.O., by continuous i.v. infusion, or by serial i.p. injection. In parallel experiments, animals also received injections of heparin, 500 U (H). Controls were given saline by the corresponding route plus chow, or chow only. Animals were bled by aortic puncture at 48 hrs. F averaged 266 ± 0.14 (SEM) mg% in untreated and p.o. controls, 549 ± 0.35 mg% in i.v. controls, and 349 ± 0.54 rag% in i.p. controls. These differences in control values may reflect stress effects of confinement or injection (FFA release?). F in rats receiving IL or IL + H, respectively, increased by 21% (N.S.) and 71% (p < 0.01) in the p.o. series; 70% (p< 0.001) and 63% (p < 0.001) in the i.v. series; and 87% (p < 0.001) in the i.p. series. Thus, F increased significantly when fat was infused directly (i.v.) or indirectly (i.p.) into the circulation, or when H was administered with IL p.o. In contrast, IL administered p.o. without H had no effect on F. These results indicate that i.v. therapy with IL may be followed by a significant rise in F, with potential increase in blood viscosity and decrease in peripheral blood flow in polycytnanic or severely stressed infants.

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