Abstract
The present study was carried out to determine the incidence and clinical manifestations of GBD in children with SS. Thirty-two SS patients ranging in age from 2 to 17 years (mean 9.3) had oral cholecystography (OC) performed and in addition 6 of these had sonography. On OC 6 patients aged 17, 16, 16, 13, 6 and 3 years had evidence of GBD. Two had non-opaque and one opaque stones and in 3 there was no visualization after repeat OC with a double dose of telepaque. Of the 6 patients who had sonography 2 were normal and 4 had abnormal gall bladders consistent with chronic choleystitis without demonstrating cholelithiasis. OC on these 6 patients revealed that 2 had normal gall bladders, 3 had non-functioning gall bladders and 1 had non-opaque stones.
GBD in these patients did not seem to correlate with the incidence of painful abdominal crises. The incidence of GBD in this series was 18% which is higher than that previously reported in children with SS. Since the incidence of severe symptoms and/or complications of cholelithiasis is about 50$ with an overall mortality of 2.7% within the first five years in unoperated patients (Lund, J.: Ann. Surg. 151:153, 1960) the presence of gallstones in children with SS is an indication for elective cholecystectomy.
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Karayalcin, G., Jou, A., Aballi, A. et al. GALL BLADDER DISEASE (GBD) IN CHILDREN WITH SICKLE CELL DISEASE (SS). Pediatr Res 11, 473 (1977). https://doi.org/10.1203/00006450-197704000-00619
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DOI: https://doi.org/10.1203/00006450-197704000-00619
