Abstract
Proximal renal tubular damage is reflected by increased urinary enzyme activity. The urinary enzymes muramidase (MUR), Beta glucuronidase (BG) and N-acetyl-glucosaminidase (NAG) were determined in infants and children receiving gentamicin, and compared to age matched controls.
No significant decline in GFR as reflected by serum creatinine and BUN was observed in the gentamicin treated group. However, urinary enzyme activity in both infants and older children receiving gentamicin therapy was significantly higher than in controls, indicating proximal tubular injury. Urinary enzyme activities in neonates were significantly higher than in older children.
Urinary enzyme activities are a sensitive means of detecting gentamicin tubular toxicity.
*Mean activity ± SEM expressed as U/mg of urinary creatinine.
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Adelman, R., Zakauddin, S. & Gold, E. 1043 URINARY ENZYME ACTIVITY IN PATIENTS RECEIVING GENTAMICIN THERAPY. Pediatr Res 12 (Suppl 4), 537 (1978). https://doi.org/10.1203/00006450-197804001-01049
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DOI: https://doi.org/10.1203/00006450-197804001-01049
