Abstract
The cardiovascular effects of CPPB were examined in 11 anesthetized 1 week old piglets. Mean aortic pressure (BP), heart rate (HR), central venous pressure (CVP), carotid (C), femoral (F) and renal (R) flows (f) and resistances (r), were determined at three levels of positive end expiratory pressures (PEEP) 1.5, 5.0, and 10 cm H2O. The peak airway pressures at each PEEP were selected to maintain constant ventilation. The results are expressed as percent change ± SE between levels of PEEP: (*p ≤.05)
These data demonstrate increases in HR, BP, CVP and r with falls in all flows as airway pressure increases. The newborn piglet responds in part to CPPB by vasoconstriction, with resultant dimunition in blood flow in at least three major vessels.
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Brown, D., Lipsitz, P., Nagelberg, J. et al. 1168 THE HEMODYNAMIC RESPONSE TO CONTINUOUS POSITIVE PRESSURE BREATHING (CPPB) IN NEWBORN PIGLETS. Pediatr Res 12 (Suppl 4), 558 (1978). https://doi.org/10.1203/00006450-197804001-01174
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DOI: https://doi.org/10.1203/00006450-197804001-01174
