Abstract
Eighty five boys and fourty nine girls aged 3 months to 16 years and without endocrine pathology received 25ug/m2 LHRH (Hoechst) i.v. Boys and girls were distributed into six groups according to bone age (I: 3-6 mo, II: 6 mo-2 yr, III: 2-9 yr, IV: 9-11 yr) or to stage of puberty (V: P2, VI: P3). Serum LH and FSH were measured by radioimmunoassay methods. Basal LH and FSH levels increased gradually from group IV throughout puberty. The lowest LH responses were observed in group II and III and were similar in both sexes. In group I, the maximal LH value seen after LHRH was some 2 times higher in boys than in girls: the response in boys was similar to that found in both sexes of group IV, although basal levels were lower. The LH responses increased further with the stages of puberty; at all stages, the values after LHRH were higher in boys than in girls. In girls, the FSH response was the highest in group II, then it decreased steadily throughout infancy and stages P2 and P3. In boys, the FSH response was the lowest in group I and then increased steadily until stage P3.
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Caufriez, A., Wolter, R., L'hermite, M. et al. Gonadotropin response to synthetic LHRH in normal children. Pediatr Res 12, 162 (1978). https://doi.org/10.1203/00006450-197802000-00095
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DOI: https://doi.org/10.1203/00006450-197802000-00095
