Abstract
The aim of this study was to evaluate fat and nitrogen absorption in cystic fibrosis when pancreatic replacement therapy was administered with cimetidine, an H2 receptor antagonist and acid secretory inhibitor. Ten patients (mean age 13.9 yrs.) who had steatorrhea while taking large doses of enzymes were studied. Pancreatic insufficiency was confirmed by poor responses to secretin and CCK stimulation. Celiac sprue as a cause for malabsorption was eliminated by small intestinal biopsy. Calories were supplied as 40% fat, 20% protein, and 40% carbohydrate. Viokase and CotazymR were supplied at the rate of 1 tablet per 15 gms. of dietary fat. Cimetidine was given ½ hour before meals at low (L-50 mg), medium(M-100 mg), and high(H-150 or 200 mg) doses. Fecal fats and nitrogens were quantitated while enzymes alone (E) and enzymes with cimetidine (E&C) were given. Results were as follows:
When pancreatic enzymes were administered with the highest dose of cimetidine, steatorrhea was significantly reduced.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cox, K., Isenberg, J., Osher, A. et al. 415 EFFECT OF CIMETIDINE ON PANCREATIC REPLACEMENT THERAPY IN THE MALDIGESTION OF CYSTIC FIBROSIS. Pediatr Res 12 (Suppl 4), 433 (1978). https://doi.org/10.1203/00006450-197804001-00420
Issue date:
DOI: https://doi.org/10.1203/00006450-197804001-00420
