Abstract
Urinary iron excretions with DF and vit. C were evaluated over 48-hour periods in an iron overloaded 9-year-old male with congenital hypoplastic anemia. SQ DF was 85% as effective as I.V. DF. A 12-hour SQ infusion produced the highest excretion during treatment but had a significant effect for 36 hours. Dose response curves were determined for each drug with continuous 12-hour SQ infusions. Using a constant vit. C dose of 500 mg p.o./d and increasing doses of DF, 36 hr. urinary iron increased from 22.5 mg with 1 gm DF to 56.2 mg with 4 gm DF (linear correlation coefficient 0.96, p <0.01). Increasing doses of vit. C (0.5 to 3 gm/d) with a constant DF dose of 2.9 gm were not associated with significant increases in iron excretion (from 44.2 to 49.9 mg) (linear correlation coefficient 0.66, p >0.05). Continuous EKG and frequent echocardiogram monitoring showed no arrythmias or other changes in cardiac function with doses up to 3 gm vit. C. Our data shows that increased iron excretion continues for 36 hours following 12-hour SQ infusions of DF. A linear increase in excretion occurred with SQ DF doses up to 4 gm. Raising the vit. C dose from 0.5 to 3 gm per day did not result in a significant increase in iron excretion.
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Ambruso, D., Mahony, B., Githens, J. et al. 576 URINARY IRON DOSE RESPONSE TO SUBCUTANEOUS (SQ) DESFERRIOXAMINE (DF) AND ORAL ASCORBIC ACID (VIT. C) IN CONGENITAL HYPOPLASTIC ANEMIA. Pediatr Res 12 (Suppl 4), 459 (1978). https://doi.org/10.1203/00006450-197804001-00581
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DOI: https://doi.org/10.1203/00006450-197804001-00581
