Abstract
Since 1971, 7 children with AL (5 ALL, 2 ANL) have been transplanted at the University Children's Hospital. 2 of the donors were identical twins, 4 were siblings, 1 the HLA-identical father. The ALL children were transplanted after 2 to 4 relapses, the ANL earlier. 3 were in CR, 2 in PR and 2 in relapse. All got intensive chemotherapy, and 5 total body irradiation (TBI). 3 died of early complications, all others showed a take. 1 boy (w/o TBI) relapsed after 2 months, 1 with an AML had a testicular relapse after 4 months, but is in CR again since 10+ months under chemotherapy. The most recent patient shows a normal bone marrow, and no acute GvH, after 1 month. 1 boy stays in CR since 40+ mo.
Our results suggest, and those from Seattle show that bone marrow transplantation in AL is feasible. As interstitial pneumonia and relapse are the most important obstacles to success, the children should be in remission (to start with a lower tumor load) and get an intensive cytostatic pretreatment, but - to avoid pneumonitis - should not get more than 750 r to the lungs.
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Plüss, H., Sigrist, J., Sigg, C. et al. 23 INDICATIONS AND RESULTS OF BONE MARROW TRANSPLANTATION IN CHILDHOOD ACUTE LEUKEMIA (AL). Pediatr Res 13, 952 (1979). https://doi.org/10.1203/00006450-197908000-00039
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DOI: https://doi.org/10.1203/00006450-197908000-00039
