Abstract
16 patients with XO-syndrome, aged 11.1 - 16.3 years, were treated with 0.1 mg/kg oxandrolone daily. Mean bone age 11.3 ± 1.1 (SD) years, height SDS (standard deviation score) for chronological age 3.45 ± 0.94.
Pat. received oxandrolone therapy for one year (period I), no therapy for the next 6 months (period II) and oxandrolone again for further six-month periods (period III, IV).
There was a significant increase (p < 0.005) in growth velocity (cm/year) with hormone medication: pretreatment: 2.3 ± 1.2, during first and second 6 months of therapy: 5.9 ± 1.6 and 5.2 ± 0.9, during period II: 1.4 ± 1.1, period III: 4.6 ± 1.4, period IV: 4.0 ± 0.5. Bone age velocity did not differ significantly from pretreatment velocity during period I-IV. Oxandrolone treatment resulted in a significant increase (p < 0.005) in the ratio of height age: bone age. Height SDS for bone age significantly decreased (p < 0.01) with hormone administration: pretreatment: −1.72 ± 0.76, after period I: −1.41 ± 0.76, after period II: −1.69 ± 0.75, after period III: −1.49 ± 0.66 and after period IV: −1751 ± 0.62. Serious side-effects were not observed.
These data may suggest some favourable effect of oxandrolone on growth in Turner's syndrome.
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Stahnke, N., Willig, R. Effects of Oxandrolone on Growth in Turner's Syndrome. Pediatr Res 13, 1194 (1979). https://doi.org/10.1203/00006450-197910000-00085
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DOI: https://doi.org/10.1203/00006450-197910000-00085
