Abstract
Unlike most assays for detecting IC, the platelet aggregation test (PAT) detects both complement and non-complement fixing IC. The platelet aggregating material (PAM) is not monomeric antiplatelet antibody, thrombin or platelet aggregating factor, and has a molecular weight consistent with IC. We compared PAT with Clq binding and Raji cell assays in sera from patients with different forms of nephritis including minimal change glomerulonephritis. In minimal change glomerulonephritis, 64% of sera showed the aggregating titre 1/4 or greater (most of the normal subjects showed the titre 1/2 or less). Raised levels of PAM (> 1/4=10μg/ml IgG) were found in membranous nephropathy (MN)(81%), HSP nephritis (83%),postinfectious nephritis (100%),SLE (65%) and MCGN (89%) ; the other two assays were only occasionally positive in MN and HSP nephritis. In HSP, IgG IC, presumably non-complement fixing IC,rather than IgA IC are associated with more severe nephritis (Lancet ii,1100,1979). The simpler,quicker and cheaper PAT, which reacts with a wide range of IgG IC may be useful in monitoring treatment and assessing prognosis in these diseases.
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Kasai, N., Chantler, C., Parbtani, A. et al. PLATELET-AGGREGATING IMMUNE COMPLEXES (IC) IN CHILDREN WITH IDIOPATHIC AND HENOCH-SCHÖNLEIN PURPURA (HSP) NEPHRITIS.. Pediatr Res 14, 998 (1980). https://doi.org/10.1203/00006450-198008000-00148
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DOI: https://doi.org/10.1203/00006450-198008000-00148
