Abstract
Fasting high density lipoprotein cholesterol (HDLC, Bernstein method) and total cholesterol (TC) were measured in 36 children aged 1.9 - 18.5 years with a history of nephrotic syndrome and a GFR > 70ml/min/1.73m2. The nephrotic syndrome was steroid sensitive in 23, due to focal glomerulosclerosis (FSGS) in 11,and other nephritis in 2. 21 samples were collected in relapse (serum albumin < 30G/L), 5 in partial remission (proteinuria with serum albumin >30G/L) and 18 in complete remission. 15 healthy children matched for age and sex served as controls. Mean TC was higher in relapse (12.6mmol/L ± 4.3 SD) than in complete remission (7.4 ± 3.0 SD, p<0.001) or in controls (5.2 ± 1.0 SD, p<0.001). TC correlated negatively with serum albumin (r=-0.62). Mean HDLC was higher in relapse (2.64 ± 1.31 SD, p<0.001)and in complete remission (2.66 ± 1.08 SD, p < 0.001) than in controls (1.37 ± 0.37 SD). HDLC correlated positively with serum albumin (r=0.60) in children in relapse. Only 2 children, both with FSGS, had HDLC/TC ratios below normal, and in only 1 was HDLC below normal. Prednisolone caused no significant alteration in HDLC or TC. If low HDLC predisposes to cardiovascular disease, few children with nephrotic syndrome would appear to be at risk.
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Morris, M., Waas, V., Jones, R. et al. HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVELS IN CHILDREN WITH THE NEPHROTIC SYNDROME - A POSSIBLE RISK FACTOR FOR CARDIOVASCULAR DISEASE?. Pediatr Res 14, 999 (1980). https://doi.org/10.1203/00006450-198008000-00157
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DOI: https://doi.org/10.1203/00006450-198008000-00157
