Abstract
In normal subject, during a continuous infusion of gluoose (1.15 mmol/min. m2) and insulin (42 mU/min, m2), the endogenous insulin secretion is inhibited ; the mean steady state plasma glucose (SSPG) and insulin (SSPI) levels are achieved after 90 min. The SSPG is of 6.6 mM, It was generally accepted that the SSPG reflects individual insulin sensitivity. 18 children withou acidosis starting a diabetes mellitus received such an infusion during 4 hours. Under these conditions SSPG, SSPI and SSPFFA levels are achieved after 120 or 180 min. SSPG level varies from 4.4. to 17.8 mM. SSPI level is of 45 ± 8 uU/ml.
There is no relationship between the SSPG level and SSPI, SSPFFA and acetonuria, between the SSPG level and the baseline value of cortisol, glucagon, alanine, as well as the highest level of C. peptide. The rate of FFA decreases similarly, whatever rate achieved at the SSPG. However there is a correlation (p < 0.01) between the SSPG level and the FFA and the triglyceride levels at baseline. These results show that in diabetic children without acidosis, there is a great variability of the insulin sensitivity. The initial levels of the triglycerides and of the FFA are closely correlated to this sensitivity.
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Dieterlen, P., Grasset, E., Deschamps, I. et al. INVESTIGATION OF INSULIN SENSITIVITY IN 18 CHILDREN STARTING A DIABETES MELLITUS: 53. Pediatr Res 14, 174 (1980). https://doi.org/10.1203/00006450-198002000-00080
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DOI: https://doi.org/10.1203/00006450-198002000-00080
