Abstract
Comprehensive endocrinological investigations were performed in a 15 yr old girl with XO-GD during AN and after recovery. This is the 10th report and first endocrine study of this combination. Basal parameters before, during and after recovery from AN were as follows:
LH and FSH after LH-RH showed a prepubertal pattern during the anorectic stage and after recovery rose back to the castration range. TSH and PRL increases after TRH were normal but prolonged during AN and several months after recovery. There was a marked paradoxic rise of hGH after TRH, LH-RH and oral glucose, which decreased after recovery. These findings are in concordance with dynamic endocrine profiles we found in 21 pubertal girls with AN. It seems to be the only condition to abolish the hypergonadotrophic state of GD, by reducing the negative feedback threshold back to its prepubertal level. This supportsthe hypothesis of a reversible hypothalamic dysfunction in AN.
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Kauli, R., Gurewitz, R., Galatzer, A. et al. Endcrine studies in anorexia nervosa (AN) concurrent with XO gonadal dysgenesis (GD). Pediatr Res 15, 90 (1981). https://doi.org/10.1203/00006450-198101000-00113
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DOI: https://doi.org/10.1203/00006450-198101000-00113
