Abstract
Patients with SCD (n=174) immunized with PV had a high rate (70%) of mild reactions, primarily at the site of injection and directly associated (p <0.01) with the level of preimmunization pneumococcal IHA Ab titer. Ab response to different antigens followed 3 patterns: poor or good response regardless of age at immunization and improving response with advancing age at immunization; increase in Ab was strongly correlated (p <0.0005) with increasing level of preimmunization Ab.
In 24 months of surveillance 3 episodes of type 23 pneumococcal sepsis were documented in study patients: 2 children under age 30 months (incidence, 4.40/100 patient years in children age 1-4 years) and a child age 5.6 years (0.66/100 patient years in children ≥5 years). The incidence of pneumococcal sepsis among nonimmunized children age 1-4 years followed at Los Angeles County-University of Southern California SCD Center was 6.20-9.03/100 patient years.
Therefore, anamnestic response seems to contribute strongly to the enhanced Ab response observed in older children. Only modest vaccine protection may be expected among children with SCD who receive a single dose of PV.
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Rigau Perez, J., Overturf, G. & Powars, D. 861 PNEUMOCOCCAL IMMUNIZATION OF PATIENTS WITH SICKLE CELL DISEASE (SCD): REACTIONS AND ANTIBODY (Ab) RESPONSE. Pediatr Res 15 (Suppl 4), 586 (1981). https://doi.org/10.1203/00006450-198104001-00886
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DOI: https://doi.org/10.1203/00006450-198104001-00886
