Abstract
NKC is an important antiviral defense mechanism. Neonates have low NKC to HSV infected cells. Human blood MC cultured for 18 hr. with HSV infected cells produced a lymphokine which stimulated adult MC-NKC from 53.0 ± 10.5% to 79.8 ± 12.8%, (p<.01)in an 18 hr. 51Cr release assay against HSV infected target cells. This resulted in a calculated lymphokine-dependent cellular-cytotoxicity (LDCC) of 65.8%. No active lymphokine was produced in the presence of uninfected cells. LDCC lymphokine production was independent of MC donor HSV serology. Cells from colostrum of most (8/10) women also produced an HSV stimulated lymphokine which mediated adult MC-LDCC (19.6 ± 4.2%) and was greater (p<.05) than matched MC lymphokine activity (6.7 ±2.6%) from these women. CC lymphokine production was also independent of donor HSV serology. Similarly, most (10/13) CC lymphokine cultures could stimulate neonatal MC-LDCC (17.4 ± 11.1%) as well as adult MC-LDCC.
Colostral cell stimulation of neonatal NKC by LDCC may account for the increased non specific resistance of breast fed infants to viral infection.
Supported by NIH grants 1 P01HD 13021 and Al 14450
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Kohl, S., Pickering, L. & Loo, L. 938 COLOSTRAL CELL (CC) LYMPHOKINE STIMULATION NEONATAL MONONUCLEAR CELL (MC) NATURAL KILLER CYTOTOXICITY (NKC) TO HERPES SIMPLEX VIRUS (HSV) INFECTED CELLS. Pediatr Res 15 (Suppl 4), 599 (1981). https://doi.org/10.1203/00006450-198104001-00963
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DOI: https://doi.org/10.1203/00006450-198104001-00963
