Abstract
Sepsis remains one of our major unresolved problems. The prostaglandin synthetase inhibitor, indomethacin(IND) improves survival in endotoxin and sepsis models. However, the protective mechanisms are unknown. We injected the peritoneum of 70 male rats(250-300g) with 1.25×1010 E.coli organisms(LD80). After 1hr.35 controls received IP injection of 2cc normal saline, and the other 35 received IP IND 3mg/kg(2cc). Survival was increased from 17% in the controls to 43% in the IND group(p<.02). To investigate the possibility that IND improves survival by attenuating the circulatory and clotting abnormalities, we performed the following study in 25 additional rats, measuring mean arterial pressure(MAP) by carotid artery cannulation.
We conclude that IND decreases coagulation and hemodynamic abnormalities in gram negative sepsis and shock. This agent may become a useful adjuvant to therapy.
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Short, B., Gardiner, M. & Fletcher, J. 1071 INDOMETHACIN IMPROVES HEMODYNAMIC AND CLOTTING STUDIES IN E.coli SEPSIS. Pediatr Res 15 (Suppl 4), 621 (1981). https://doi.org/10.1203/00006450-198104001-01097
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DOI: https://doi.org/10.1203/00006450-198104001-01097
