1243 ASSOCIATION OF EARLY AORTOGRAMS & PDA LIGATION WITH INTRAVENTRICULAR HEMORRHAGE (IVH)

Abstract

Thirty-three sick infants (<34 wk gest.) with RDS, PDA & subependymal hemorrhage (SEH) &/or minor IVH (without ventricular enlargement) were followed with frequent ultrasound brain studies to detect changes in IVH/SEH. Twenty-six had PDA ligation before 96 hours of life (“early”) & 7 after 96 hrs (“late”). Sixteen of 23 infants increased their IVH/SEH after early ligation. No changes occurred in those ligated late.

Ligated infants who increased tneir IVH/SEH had aortograms more frequently than infants without IVH/SEH change. Both procedures might result in an acute increase in arterial blood pressure in infants lacking cerebral blood flow autoregulation. Early PDA ligation preceded by aortogram may be a risk factor for major IVH/SEH.

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