Abstract
ICH may evoke systemic and local changes in the forces which modify fluid flux between intravascular and interstitial spaces. The relation of these changes to alterations in blood COP was studied in 9 infants with ICH, diagnosed by real time B ultrasound CNS scanning during the first 72 hours postnatally. Their mean B.Wt. = 1322.5g and mean G.A. = 30.6 wks. COP was measured with a Wescor Colloid Osmometer (Model 4100) on the first and third postnatal days. Six other infants with comparable B.Wt. and G.A. but without ICH, as confirmed by ultrasound, were studied similarly. In infants with ICH the mean COP was 11.6 ± 1.1 and 15.0 ± 1.8 mmHg on the first and third day. This rise in COP was highly significant (p<.001). Infants without ICH had mean COP of 13.4 ± 1.2 and 13.6 ± 2.8 mmHg on the corresponding days. Rupture of cerebral blood vessels may stimulate axone reflexes producing vasodilation resulting in a rise in capillary blood pressure which may be independent of changes in arterial pressure. An excess of capillary blood pressure over COP leads to filtration of fluid from intra to extravascular spaces resulting in a rise in intravascular COP and development of interstitial edema.
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Wu, P., Sims, M., Udani, V. et al. 1468 INTRACRANIAL HEMORRHAGE (ICH) AND CHANGES IN COLLOID OSMOTIC PRESSURE (COP). Pediatr Res 15 (Suppl 4), 688 (1981). https://doi.org/10.1203/00006450-198104001-01497
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DOI: https://doi.org/10.1203/00006450-198104001-01497
