Abstract
In a group of 15 patients with hiperinsulinic hypoglycemia we studied the response to Diazoxide treatment. Glucose (O.G.T.T.), Glucagon, leucine and milk have been used as provocative tests for insulin release. The insulin was measured by radioim-munoassay. The hiperinsulinism demonstrated in all patients in response to some of the stimuli was treated with Diazoxide 10mg/Kg/day. After 10 days of treatment the response was evaluated by O.G.T.T. and/or milk test.
Partial or total pancreatectomy was performed in five patients who didn't improve with treatment. Pathologic lesions were as follows: 3 neisidioblastosis, 1 islet cell adenoma and 1 islet cell hyperplasia and hypertrophy.
From our data we concluded:
1° Children who failed to respond to Diazoxide had pathologic lesions in the pancreas.
2° Glucagon seems to be the best stimulus to evaluate this patients.
Furthermore, the milk test has shown to be easy and valuable for evaluation of the therapeutic effect of Diazoxide.
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Cayssials de Buera, A., Mazza, C. 17 EVALUATION OF DIAZOXIDE TREATMENT IN CHILDREN WITH HIPERINSULINIC HYPOGLYCEMIA IN THE FIRST YEAR OF AGE. Pediatr Res 15, 186 (1981). https://doi.org/10.1203/00006450-198102000-00074
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DOI: https://doi.org/10.1203/00006450-198102000-00074
