Abstract
In order to study a possible action of beclomethasone spray, a corticosteroid drug used succesfully in treatment of bronchial asthma, on the hypothalamo-hypophyso-adrenal cortex system, 8 chronic asthmatic children 8 to 14 years old, free of corticosteroid treatment for at least 6 months prior to analysis were evaluated before and after 3 months on 300ug of beclomethasone spray daily. Urinary excretion of 17OHCS and THS, and serum concentrations of F and S, in basal conditions (B), during and one day after metopirone (M) were measured. 17-OHCS excretions before and after treatment were B: 3.81 ± 0.47 and 2.89 ± 0.43, post M 9.15 ± 0.63 and 6.63 ± 1.31, THS excretion B undetectable and post M 2.95 ± 0.73mg/d,. Serum concentrations of F, B: 9.09 ± 0.54 and 7.16 ± 0.68, M 3.90 ± 0.62 and 4.05 ± 0.34 and S, B: 0.51 ± 0.17 and 0.39 ± 0.16, post M 10.50 ± 2.09 and 8.39 ± 1.61 ug/100ml (X ± SE). No significative differences were observed under beclomethasone. It is concluded that the beclomethasone spray in the used doses, didn't inhibit the hypothalamo-hypophyso-adrenal axis in these children.
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Vilma, D., Marta, A., Recoba, G. et al. 43 HYPOTHALAMO-HYPOPHYSO-ADRENAL SYSTEM IN ASTHMATIC CHILDREN UNDER BECLOMETHASONE TREATMENT. Pediatr Res 15, 190 (1981). https://doi.org/10.1203/00006450-198102000-00100
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DOI: https://doi.org/10.1203/00006450-198102000-00100
