Abstract
A-II was infused in 17 chronically catheterized fetal (F) lambs (116-131 days gestation) and in 7 nonpregnant adult (A) ewes. The rates of A-II infusion in F and A were adjusted to compare the effect of similar plasma A-II concentrations (pA-II) on plasma Aldo, PRA, arterial pressure (MABP); it was found that the rate of A-II infusion had to be about 5 times higher in F than in A to reach similar pA-II. The effect of A-II infusion in F and A were studied at 3 different levels of pA-II.
(* for p<0.05 when values during A-II infusion are compared to control values; † for p<0.05 when pA-II values in F are compared to A values.) The A-II plasma clearance rate was significantly (p<0.001) higher in F (179±16 ml/min/kg) than in A (40±3 ml/min/kg). The present results indicate that A-II stimulates Aldo and inhibits renin production in fetal life. It is also suggested that the responsiveness to an increased concentration of pA-II is lower in F than A.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Robillard, J., Smith, F. 286 MODULATION OF PLASMA ALDOSTERNONE (Aldo) CONCENTRATION AND PLASMA RENIN ACTIVITY (PRA) BY ANGIOTENSIN-II (A-II) DURING FETAL LIFE. Pediatr Res 15 (Suppl 4), 487 (1981). https://doi.org/10.1203/00006450-198104001-00297
Issue date:
DOI: https://doi.org/10.1203/00006450-198104001-00297
