Abstract
The ventricular septum has increased numbers of insulin receptors. Isoxsuprine (ISX) has been reported to cause increased cord blood insulin. To demonstrate whether an association between ISX exposure, hyperinsulemia and ASH occurred Echocardiography (EC) was performed on 30 infants who had ISX exposure and 25 control infants. Normal septal thickness is 3-4 mm.
The control septal thickness was .38±.04. The ISX septal thickness was .55±.13. These are significantly different at p < .005.
The ISX treated infants were larger, had thicker ventricular septae and had higher cord insulin levels than non or partially treated controls. ISX as a tocolytic agent may have a similar effect on the fetus as maternal diabetes.
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Crawford, C., Bowen, F., Bhutani, V. et al. 321 ECHOCARDIOGRAPHIC EFFECTS OF INTRAUTERINE ISOXSUPRINE EXPOSURE. Pediatr Res 15 (Suppl 4), 493 (1981). https://doi.org/10.1203/00006450-198104001-00332
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DOI: https://doi.org/10.1203/00006450-198104001-00332
