Abstract
GH stimulates gastric mucosal growth and function (Crean, Vitamins Hormones 21:215,1963). In order to determine if hGH affected gastrin secretion, serum concentrations of this peptide were determined by radioimmunoassay for three hours during a standard test meal (2 boiled eggs, 2 pieces buttered toast, 8 ounces skim milk) in patients with hyposomatotropism prior to initiation of treatment (N=14) and after six (N=12) and 12 months (N=10) of hGH administration (0.1 U/kg thrice weekly). Basal and peak concentrations (pg/ml) of gastrin were:
(a. p <0.01, b. p <0.05 versus basal by paired t test)
Gastrin concentrations increased during feeding at each period. The peak gastrin concentration after 12 months of hGH administration was significantly (p <0.05) lower than the peak value recorded prior to initiation of treatment. Peak serum insulin concentrations in response to the standard meal did not change significantly during hGH administration [pre Rx- 28 ±6 uU/ml (N=13); +6 months 39 ±12 (N=7); +12 months 31± 6 (N=9)]. It is concluded that long term administration hGH is associated with slightly depressed gastrin secretory response to feeding.
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Root, A., Aurltt, A. & Livingston, C. 626 DECREASED GASTRIN SECRETION EVOKED BY FEEDING DURING ADMINISTRATION OF HUMAN GROWTH HORMONE (hGH). Pediatr Res 15 (Suppl 4), 545 (1981). https://doi.org/10.1203/00006450-198104001-00639
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DOI: https://doi.org/10.1203/00006450-198104001-00639
